MICCAI MeshMed 2012, a workshop on mesh processing in medical image analysis, was held at the Acropolis Convention Center in Nice, France on October 1, 2012 in conjunction with the MICCAI 2012 conference. The MeshMed series of workshops was initiated in 2011 with the first event successfully held in conjunction with MICCAI 2011. The primary goal of this event was to bring together the geometry processing, computer graphics, and medical imaging communities to foster joint efforts and specific research. A fundamental theme, the image analysis pipeline and the significant role of geometric computation within it, was a central focus of the submitted works and discussions. Many of the technologies currently being developed by researchers in these communities are done so in an independent and isolated manner. We believe there is significant, fruitful research to be done that requires cross pollination of the geometry and imaging communities. Developing a more sophisticated understanding of the interplay between surface and volume representations (meshes) and clinical analysis and simulation is of utmost importance.